MOST READ OSG plea to revoke ABS-CBN franchise ’a duplicitous move’ – Lacson Steam emission over Taal’s main crater ‘steady’ for past 24 hours While San Miguel has thrived in this tournament, Meralco has gone the exact opposite. The Bolts have won just a combined four games in the last two seasons under Black, who continues to look for a dominant man in the middle.Instead, the Bolts landed KG Canaleta from the free agent market, and the journeyman gunslinger repaid Black’s trust in their debut by shooting 25 points against his former team.Sports Related Videospowered by AdSparcRead Next Eagles abound in pro league Meralco ‘never the same’ after Almazan injury in PBA Finals View comments Redemption is sweet for Ginebra, Scottie Thompson OSG plea to revoke ABS-CBN franchise ’a duplicitous move’ – Lacson Lights inside SMX hall flicker as Duterte rants vs Ayala, Pangilinan anew Tristan Tamayo/INQUIRER.netWith the entire field wanting to shoot it down, defending champion San Miguel Beer returns to action Wednesday and will put Meralco to the test in the PBA Philippine Cup as they jostle for the early elimination round lead at Ynares Center in Antipolo.Coming off an impressive 104-96 decision of Phoenix Petroleum in the inaugurals, the Beermen will slug it out with the Bolts in the 7 p.m. contest.ADVERTISEMENT LATEST STORIES Don’t miss out on the latest news and information. Carpio hits red carpet treatment for China Coast Guard PLAY LIST 02:14Carpio hits red carpet treatment for China Coast Guard02:56NCRPO pledges to donate P3.5 million to victims of Taal eruption00:56Heavy rain brings some relief in Australia02:37Calm moments allow Taal folks some respite03:23Negosyo sa Tagaytay City, bagsak sa pag-aalboroto ng Bulkang Taal01:13Christian Standhardinger wins PBA Best Player award Scottie Thompson also worthy of Finals MVP, thinks Cone Brian Heruela arrival bolsters Phoenix backcourt, defense Meanwhile, the Fuel Masters try to rebound from that defeat when they battle Kia Picanto in the 4:15 p.m. game.“The field improved their rosters and their battlecry is to beat San Miguel Beer,” Austria went on. “But every time there’s pressure, my players play with the sense of urgency. They are still hungry [to win] the title.”No team has achieved a four-peat in this conference, and San Miguel has come out on top of practically everyone’s list as the team to beat.And Black’s problem will be Fajardo, with Meralco not having the player that can stop the the 6-foot-10 star one-on-one.“I think we have a better team than the one last season,” Black added.ADVERTISEMENT Jiro Manio arrested for stabbing man in Marikina “They will be a handful,” Meralco coach Norman Black said of the Beermen, after his Bolts also had a shaky debut against the Blackwater Elite a week ago.San Miguel coach Leo Austria didn’t hide his strengths in the win over Phoenix, calling on his starting unit to do practically all of the offensive damage on the Fuel Masters.FEATURED STORIESSPORTSTim Cone, Ginebra set their sights on elusive All-Filipino crownSPORTSGinebra beats Meralco again to capture PBA Governors’ Cup titleSPORTSAfter winning title, time for LA Tenorio to give back to Batangas folkAgainst Phoenix, Austria’s first five scored all but nine of the total San Miguel output, with reigning four-time Most Valuable Player June Mar Fajardo finishing with 23 points, 16 rebounds and four blocks.“The first win is really hard [to get], especially because everyone is preparing very hard for us,” Austria said.
Source:http://www.unibe.ch/ Jul 30 2018An international research team under the co-direction of the University of Bern and the Netherlands Cancer Institute (NKI) has discovered various mechanisms of resistance to cancer therapy. The findings help researchers to understand the self-repair of cancer cells after a therapy and thus help to fight resistant tumors more efficiently.The DNA in our cells is constantly subjected to damage, caused in particular by the cells’ normal metabolism. Current estimates assume up to 70,000 impairments per cell per day. Healthy cells can repair this damage, however, using the proteins BRCA1 and BRCA2, for example. If they are defective though, this leads to an increased number of DNA mutations, which can cause cancer. Damage to these two repair proteins is associated above all with the occurrence of breast and ovarian cancer. Tumors with such a defect can be fought using a new therapy with so-called PARP inhibitors. If the protein PARP, which also plays a role in DNA repair, is blocked as well as the defective repair proteins, the cancer cells die off while the healthy body cells (with still functioning repair proteins) survive. Unfortunately, despite the clinical success of the PARP inhibitors, patients often develop a resistance. The precise causes for this resistance are still unclear.In close cooperation with the Netherlands Cancer Institute (NKI) in Amsterdam (Jonkers Laboratory), the Institute of Cancer Research in London (Lord Laboratory), the Lunenfeld-Tanenbaum Research Institute in Toronto (Durocher Laboratory), and the Genome Integrity Laboratory in Oxford (Chapman Laboratory), a research team from the University of Bern has now identified four different resistance mechanisms against these PARP inhibitors. The findings can be used to develop new approaches for tackling therapy resistances. Thanks to this research, new insights have also been obtained into the fundamental mechanisms of DNA repair. The results have been published in the “Cancer Cell”, “Cell Reports”, and “Nature”.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskResearchers use AI to develop early gastric cancer endoscopic diagnosis systemStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryMillions of cancer cells examinedUsing the gene scissors CRISPR/Cas9 and targeted silencing of genes, the researchers were able to find out which genes guide DNA repair in combination with the cancer therapy. They modified millions of BRCA-mutated cancer cells genetically, although they only changed an average of 1 gene per cell. These millions of cells were then treated with PARP inhibitors, and the cells that remained, having survived the treatment, were those which had become resistant due to certain genetic changes. “The changes in these cells then indicated to us which genes are involved in the development of a resistance”, says Sven Rottenberg of the Vetsuisse Faculty at the University of Bern. In order to observe this, the researchers also cultivated the tumor cells in a three-dimensional matrix, which offers the advantage that these cell cultures are more similar to the real tumors. With these tests, the researchers discovered that the success of the PARP inhibitors depends on the functions of other proteins that are also involved in the repair of DNA breaks. If these (in part newly discovered) proteins are not functioning, resistance to PARP inhibitors develops.Exploiting the tumors’ Achilles heelNew opportunities arise from understanding the exact resistance mechanisms: “In our models, we have seen that the tumours that are resistant to treatment by PARP inhibitors – due to the deficiency of other DNA repair proteins – can be fought with radiotherapy or already established anti-cancer drugs such as temozolamide. This opens up therapeutic options for patients in which the cancer has reappeared after an initially successful treatment with PARP inhibitors”, explains Rottenberg. His research group is working on finding more weak points in the resistant tumours, with the hope of developing new therapeutic approaches and of overcoming the resistance shown by cancer that occurs due to defective repair proteins.