Tag: 上海楼凤NV

Sherwood attack on Mourinho blasted by close aide of new Spurs boss

first_imgLatest Tottenham NewsHARRY ALL FOUR ITKane admits Spurs must win EIGHT games to rise into Champions League spotGossipALL GONE PETE TONGVertonghen wanted by host of Italian clubs as long Spurs spell nears endBELOW PARRSpurs suffer blow with Parrott to miss Prem restart after appendix operationPicturedSHIRT STORMNew Spurs 2020/21 home top leaked but angry fans slam silver design as ‘awful”STEP BY STEP’Jose fears for players’ welfare during restart as stars begin ‘pre-season’KAN’T HAVE THATVictor Osimhen keen on Spurs move but only if they sell Kane this summer3“And instead of highlighting the tactical change that allowed the turnaround in the game he chose to attack Mourinho.“What’s more, selflessly, he even warned Spurs players with such shots as ‘he will have no trouble throwing them under a bus’ or ‘if he has to bury a player in public, he will’.”Written before Saturday’s game at home to Bournemouth, Parames later took to Twitter after it was confirmed Dier was in the team. He wrote: “Dier is in the 11 and Sherwood cries.”The England man played the full game at the Tottenham Hotspur Stadium.José Mourinho hails Dele Alli’s work-rate after Tottenham star continues resurgence with double vs Bournemouth TIM SHERWOOD’S attack on Jose Mourinho has been blasted as “pathetic” by the new Tottenham manager’s closest aide.Ex-Spurs midfielder and former boss Sherwood claimed the Portuguese coach will regularly throw his players “under a bus” following his substitution of Eric Dier after just 29 minutes on Tuesday.3 Tim Sherwood was not too kind in his comments on Jose Mourinho after he subbed Eric Dier off against OlympiakosCredit: PA:Empics Sport3 Jose Mourinho since apologised after hauling off Eric Dier early against OlympiakosCredit: PA:Press AssociationThe North Londoners were 2-0 down at the time to Olympiakos and after the change fought back to win 4-2.Sherwood also claimed the ex-Chelsea and Manchester United boss was happy to dig out his players in public. And his digs – on beIn Sports – have clearly angered Mourinho.Eladio Parames, who has known Mourinho since he was a child, used his column in Portuguese sports paper Record to fire back.He said: “The pathetic statements of some commentators are very annoying to me.“And they annoy me even more when they are spoken by people who, due to their sporting past, should have the good sense not to say such nonsense, especially in the media that reaches millions of people.“At the end of the match, in his first comment about the game, Mourinho made a point of apologising to Dier for his departure and explained the reasons that led him to make that decision.“He did well, because he didn’t have to, and everyone understood the reasons for the change.“Not quite everyone, because Sherwood, who was commenting on the game for a TV channel, didn’t hear the coach’s words or didn’t want to hear them, or maybe didn’t understand them.”His ‘brilliant’ coaching career leads me to admit to being the latter the most likely hypothesis.ACCA WITH LADBROKES Pick up a whole load of acca features to help you land the big onelast_img read more

Certain antibodies against a carbohydrate could protect against malaria

first_imgJul 10 2018Certain type of antibodies against α-Gal- a carbohydrate expressed by many organisms including the malaria parasite- could protect against malaria, according to a new study led by ISGlobal, an institution supported by “la Caixa” Foundation. The results, published in Scientific Reports, indicate that a-Gal is an interesting candidate to include in future vaccines against malaria and other infectious diseases.The magnitude and type of immune response against the malaria parasite is key in controlling the disease. To date, most studies have focused on the antibody response to parasite proteins. However, sugars (or glycans) expressed on the surface of the parasite could also trigger an immune response.Alpha-gal is a particularly interesting glycan: it is expressed by practically all organisms on the evolutionary scale, from bacteria in out gut, to pathogenic bacteria such as Salmonella, protozoan parasites such as P. falciparum (that causes malaria) or mammals such as cows. Only humans, apes and old-world monkeys lack the enzyme to synthesize it and generate a strong immune response against it. Recent studies suggest that antibodies to α-Gal could protect against malaria.Related StoriesNew route to quickly transport subcutaneously administered antibodies into lymph nodesAntibodies could cause arthritic painHuman liver cell protein aids development of malaria parasite, study findsIn this study, the teams led by Luis Izquierdo and Carlota Dobaño, ISGlobal researchers, joined forces to assess the magnitude and type of antibody responses against α-Gal in infants and children from Mozambique (a low malaria transmission region) and Ghana (a high transmission region). They used a technique recently developed by Dobaño’s group that allowed measuring for the first time different subclasses of antibodies against this and other parasite antigens in a single reaction and from one drop of blood.”The relevance of this study is that it provides new information on a response (anti α-Gal) that plays a potential protective role against a variety of infectious diseases, not only malaria,” explains Dobaño.The results show that the levels of different α-Gal antibodies vary according to age and are higher in low malaria transmission zones. A significant increase in IgM ?-Gal antibodies was observed in the initial months of life, while IgG antibodies increased later in life. Importantly, an IgM response was associated with protection against clinical malaria, especially in the first months of life, while total IgG were associated with malaria risk.”It would be really interesting to identify the specific α-Gal glycan expressed by the malaria parasite, and to confirm the potential association between certain IgG subclasses and protection,” says Izquierdo. “In any case, these results confirm that α-Gal could be a promising molecule to include in future malaria vaccines,” he adds.Source: https://www.isglobal.org/en/new/-/asset_publisher/JZ9fGljXnWpI/content/ciertos-anticuerpos-dirigidos-contra-un-azucar-estan-asociados-con-la-proteccion-frente-a-la-malarilast_img read more