Category: stczpq

Researchers say H1N1 virus jumped to humans months ago

first_imgJun 11, 2009 (CIDRAP News) – At almost the same moment today that the World Health Organization announced recognition of an influenza pandemic, researchers from Hong Kong, the United Kingdom and the United States declared that the novel H1N1 virus responsible has been circulating undetected in humans for months—and that its components have been present in pigs for at least a decade.The group, led by Andrew Rambaut, PhD, of the University of Edinburgh’s Institute of Evolutionary Biology, said in a letter to the journal Nature that their findings demonstrate the critical need to ramp up disease-detection efforts in animals: “Despite widespread influenza surveillance in humans, the lack of systematic swine surveillance allowed for the undetected persistence and evolution of this potentially pandemic strain for many years.”If better surveillance had existed, they suggest, the first flu pandemic in 41 years might have been detected much earlier—because the novel H1N1 strain’s evolution tracks with the emergence of earlier and (as yet) more destructive pandemic strains.”All three pandemics of the 20th century seem to have been generated by a series of multiple reassortment events in swine or humans, and to have emerged over a period of years before pandemic recognition,” they write. “Our results show that the genesis of the [swine-origin influenza A H1N1 virus] epidemic followed a similar evolutionary pathway.”The study is the third in 3 weeks to pinpoint the origin of the novel H1N1 strain of flu in pigs in North America, where it underwent complex reassortment. On May 22, a group of 60 scientists led by researchers at the Centers for Disease Control and Prevention published in the journal Science an analysis of full or partial genomes from 76 viral isolates. And on June 4, scientists from the National Autonomous University of Mexico and the University of Illinois published in Eurosurveillance an analysis of 400 protein sequences.Taken together, the three papers demonstrate an uncharacteristic scientific openness that has been allowing analysis of the novel flu to move at a record pace. In the case of today’s paper, its authors have been posting their findings piece by piece on the Internet, in a multi-author wiki (http://tree.bio.ed.ac.uk/groups/influenza/), and their paper was released by Nature without embargo, in what the journal termed a “near-final version.”To reach their results, Rambaut and colleagues compared the downloaded genetic sequences of 2 isolates of the novel flu, 15 newly sequenced Asian swine flu strains, and 796 human, swine, and avian flu isolates. In addition, using a “molecular clock” technique, they calculated the rate of viral evolution of 30 isolates of the novel flu.Their study yielded a reconstruction of the sequence of reassortment events that produced the new strain. It graphically depicts how braided and complex the evolution of the novel flu has been. Along with it, they publish phylogenetic analyses (“family trees”) for the major genomic segments of the new virus that, by depicting the time gaps between known isolates, illustrate how little surveillance of swine influenza has been carried out.They conclude that the eight genomic segments of the novel H1N1 have been circulating in swine populations for a number of years, from 9.24 years at the shortest (for the PB1 gene) to 17.15 years at the outside (for the NA gene).The complete virus, they estimate, has been circulating in humans since approximately January 2009, and may have emerged as early as August 2008.”This genomic structure may have been circulating in pigs for several years before emergence in humans,” they said. “We urge caution in making inferences about human adaptation on the basis of the ancestry of the individual genes.”Movement of live pigs between Eurasia and North America is likely to have facilitated viral reassortment, they said. Notably, they found a striking resemblance to the novel H1N1 in a 2004 swine influenza isolate from Hong Kong that contained 7 out of 8 genes similar enough for them to dub it a “sister lineage.” They caution though that this does not prove a Eurasian origin for the new flu, but only provides evidence that its swine-flu progenitors were widely geographically distributed.Smith GJD, Vijaykrishna D, Bahl J, et al. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 2009 (advance online publication Jun 11) [Abstract]See also: May 22 CIDRAP News story “Genetic study: Novel H1N1 likely originated in pigs”Garten RJ, Davis CT, Russell CA, et al. Antigenic and genetic characteristics of swine-origin 2009 A (H1N1) influenza viruses circulating in humans. Science 2009 (early online publication May 22) [Abstract]Jun 8 CIDRAP News story “Flu researchers call for enhanced swine surveillance”Nava GM, Attene-Ramos MS, Ang JK, et al. Origins of the new influenza A (H1N1) virus: time to take action. Eurosurveillance 2009 Jun 4;14(22) [Full text]last_img read more

Surrey Industrial: Belting times for the M25

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Governor Wolf Urges Passage of Pending Legislation to Combat Opioid Epidemic Amid Disaster Declaration

first_img January 29, 2018 Governor Wolf Urges Passage of Pending Legislation to Combat Opioid Epidemic Amid Disaster Declaration SHARE Email Facebook Twittercenter_img Press Release,  Public Health,  Substance Use Disorder Harrisburg, Pa. – Amid the 90-day Opioid Disaster Declaration, Governor Wolf today urged the General Assembly to consider a set of pending bills aimed at furthering the declaration’s key initiatives and messages.Several pieces of legislation were passed recently, including Sen. Tom McGarrigle’s legislation allowing the Department of Drug and Alcohol Programs to regulate recovery houses that receive federal, state, or county dollars and serve individuals in recovery from substance use disorder. That bill was signed by Governor Wolf in December.“I encourage the legislature to make passage of these bills a priority. And I thank the General Assembly for passage of recent legislation and those lawmakers who have taken the initiative to draft new legislation. I commend them for sharing my commitment to help even more Pennsylvanians fight the disease of addiction and look forward to continuing our work together to combat this crisis.”Pending and new legislation includes:Senate Bill 472, introduced by Sen. Yaw, is a priority as it limits prescriptions for a controlled substance containing an opioid to seven days unless there is a medical emergency that puts the patient’s health or safety at risk.Senate Bill 391, the administration is collaborating with the legislature on a comprehensive amendment to this bill introduced by Sen. Jay Costa, which would amend the Drug and Alcohol Abuse Control Act to reflect mandatory evaluation and treatment provisions included in the Mental Health Procedures Act (MHPA), allowing an individual to be subject to mandatory evaluation and treatment if the individual has a substance use disorder and is incapable or unwilling to accept voluntary treatment and the individual presents an imminent danger or imminent threat of danger to self or others within the past 30 days.Senate Bill 978, introduced by Sen. Lisa Baker, allows home health and hospice staff to dispose of unused prescription medication following a patient’s death. Currently, those medications are the property of the patient, and when they die their possessions become part of their estate and cannot be disposed of by non-family. When these medications are opioids, the chance could increase that family members might abuse or sell them.House Bill 353, introduced by Rep. Tedd Nesbit, requires that prescriptions for Schedule II, III and IV controlled substances be completed electronically to reduce the risk of tampering or forgery.last_img read more

Mammoth renovation complete

first_imgTimber floorboards flow through the home.The couple lived in the house for about six months, gaining an understanding for how the property functioned before they started swinging sledgehammers.The transformation from there took about two years, with the couple laying new spotted gum timber floorboards, renovating the laundry, kitchen and bathrooms, replacing plumbing and electrical, and giving the house a fresh lick of paint. The kitchen is modern and sleek.The Thomas’s even knocked out a wall to create an open-plan living area.“It’s created the open plan flow,” Mrs Thomas said.“It’s got some big windows so you can see the view and its more of a big entertainment zone now.”All of the home’s living is on the upper level, with the entry opening to a hallway which leads to an open-plan kitchen, family, dining and living room.These spaces open out onto a deck, which overlooks tree tops, which is one of Mrs Thomas’s favourite spaces. The bathroom has received a recent facelift.“The house is set up so you look out over the trees and it back onto a bit of bush, so you get lots of wallabies and kookaburras.“Sitting out on the back deck in the afternoon is beautiful.” More from newsParks and wildlife the new lust-haves post coronavirus12 hours agoNoosa’s best beachfront penthouse is about to hit the market12 hours agoWho can resist a mini bar? The exterior of 3 Gyles Court, Cornubia.They had refurbished one property before, but 3 Gyles Court was on a much larger scale.“We were looking for a property to renovate and when we saw this house, the size of the home, the rooms, the position and the outlook, we saw potential for a beautiful home,” Mrs Thomas said.center_img Sitting outside is one of Mrs Thomas’ favourite spots.Towards the end of the house are four bedrooms, including the master, which has a walk-in wardrobe and ensuite.There is also a bathroom, separate powder room and a laundry.The property is being marketed by Kati Hempenstall of Belle Property Cornubia — Shailer Park. The bedroom is spacious.Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 0:51Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:51 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD576p576p432p432p270p270pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenStarting your hunt for a dream home00:51 Check out that leafy outlook!Peta and Steve Thomas were looking for a project when they bought their Cornubia property about three years ago.last_img read more

Deutsche Bucht Monopile Foundation Turbines Up and Running

first_imgAll 31 monopile foundation wind turbines have been commissioned at the Deutsche Bucht offshore wind farm, according to Northland Power.The commissioning phase of the 31 MHI Vestas 8.4MW turbines began in early June, with all the planned work said to be completed ahead of schedule.As reported, the 31 monopile foundation wind turbines were installed at the project site in the German North Sea at the end of August.The installation and cabling for the wind farm’s remaining two turbines which will be installed on mono bucket foundations are planned for the fourth quarter of 2019.The 269MW Deutsche Bucht offshore wind farm, which delivered first power to the German grid at the end of July, is expected to be operational by the end of the year.last_img read more

Just how safe is RU 486?

first_imgABC 24 Sept 2013These are the bare bones of the long coming of “medical” abortion to Australia. The history behind these recent developments is far more complicated – and far from finished.Together with colleagues, Professor Janice Raymond and Dr Lynette Dumble, I have been researching the RU 486 abortion story since 1988, when what was then called “the French abortion pill” made its debut on the world-stage. As long-term women’s health researchers and supporters of safe abortion, we watched in astonishment as many international women’s health groups uncritically greeted the arrival of this chemical abortifacient. We wondered why the progesterone antagonist RU 486, a largely untested chemical, was hailed as a new “miracle drug” and the “moral right of women.”The result of our three-year investigation was the book RU 486: Misconceptions, Myths and Morals, published in 1991. We concluded that the “safe-and-effective” mantra that RU 486/PG abortion had acquired was misleading: the adverse effects of the two drugs were unpredictable and dangerous and the research undertaken inadequate. The new “demonising” of suction abortion as “surgical” abortion (conjuring up knives and requiring a general anaesthetic, both wrong) was worrying. We said that the drawn-out and painful process of chemical abortion (our preferred term; but I also use pill abortion or “medical” abortion) was emotionally and physically hard on the women. The abortion process lasts a minimum of three days – when all goes well – but women can bleed up to 6 weeks. Moreover, between 5 and 8% of women need a second abortion when the drugs fail to completely terminate their pregnancy and remaining products of conception need to be removed to prevent an infection. This is a very draining and unpredictable time for women, especially so when compared to the 15-30 minutes a suction abortion takes in the relative safety of a clinical setting. In particular, we worried that because the second drug, the prostaglandin, is taken outside a clinic, the woman’s life would be at risk if she was haemorrhaging excessively and needed a blood transfusion but was away from an emergency clinic.We concluded that the RU 486/PG abortion had the making of a new wave of DIY backyard abortions which burdened women who had decided they needed an abortion with unnecessary days of agony: haemorrhaging, vomiting, cramping and the well-founded fear of sepsis. We predicted deaths and also wondered why pro-choice activists could not see that this abortion method only benefited pharmaceutical companies and doctors. For the latter, it is much easier to prescribe pills than actually perform an abortion: only die-hard abortionists “like” to do them, while most other doctors perform them out of a sense of duty. We warned that the push for RU 486/PG – especially when it is cheap – could be particularly dangerous for poor and/or Indigenous women.… To update the events of the past years, in July 2013, we re-issued RU 486: Misconceptions, Myths and Morals, for which I have written an extensive 100-page preface. In my new “Preface” I ask “what is a safe and effective abortion?” and include information on birth defects both drugs can cause, contraindications that are vital for women to observe (such as asthma, epilepsy, kidney and liver disease), and the total lack of any research into long-term health risks (like a woman’s fertility). I include women’s stories of extraordinarily drawn out, scary and painful pill abortions, I mention the 15 FDA-documented deaths of women by 2011… “Regardless of one’s views on abortion, pushing this drug combo as simple is disrespectful of a woman’s right to know what she might face.” Correct.http://www.abc.net.au/religion/articles/2013/09/24/3855497.htmlast_img read more

Plane Crash: Mother and child rescued after 5 days in Colombia…

first_imgThey discovered the doors of the plane ajar and suspected that survivors may have clambered out. A mother and her infant son who disappeared in a plane crash in the dense jungles of northwestern Colombia several days ago were found alive and well in what authorities called a “miracle.”Nelly Murillo, 18, and her son Yudier Moreno, not yet one year old, were near the site where the Cessna 303 crashed on Saturday in thick brush.“It’s a miracle. It is a very wild area and it was a catastrophic accident,” Colonel Hector Carrascal, commander of the Colombian Air Force in Antioquia department, told AFP on Wednesday.“His mother’s spirit must have given him strength to survive.”Baby Yudier Moreno was held by a rescuer on the flight back to Quibdo Murillo and her baby were taken by helicopter to a nearby hospital with minor injuries, said Carrascal, adding that he was stunned they were alive.“The lady has wounds and minor burns and apparently the child is unharmed,” the Colombian Air Force said in a statement.The plane’s pilot, Captain Carlos Mario Ceballos, died in the crash and rescuers found his body in the aircraft.They discovered the doors of the plane ajar and suspected that survivors may have clambered out.A 14-person search-and-rescue team scoured the dense forest for several days before finding the mother and child.The plane was traveling between Nuqui and Quibdo in northwest Colombia when it crashed.Investigators were looking at the cause.last_img read more

IOC Twitter accounts hacked by cyber group OurMine

first_imgTwitter accounts controlled by the International Olympic Committee (IOC) have  been hacked by cyber group OurMine. Loading… A post from the hacking group appeared on handles belonging to the IOC, including the official Olympics and IOC Media accounts, this evening. The Athlete365, Youth Olympic Games and official Rio 2016 accounts were among the others affected. A spokesperson for the IOC confirmed the organisation was investigating “a potential breach into some of its social accounts”. “Hi, we are OurMine,” the post, seemingly published simultaneously across the IOC’s Twitter pages, read. “Everything is hackable. “To improve your accounts [sic] security, contact us: contact@ourmine.org.” The message has been removed from all affected pages.Advertisement It marks the latest cyber attack by OurMine, which describes itself as “an elite hacker group known for many hacks showing vulnerabilities in major systems”. OurMine, which frequently uses cyber vandalism to advertise its services, also targeted the official Twitter accounts of Spanish giants FC Barcelona for the second time. The English and Spanish language pages owned by the famous La Liga club were hijacked by OurMine back in 2017. Twitter, Facebook and Instagram accounts of 15 National Football League (NFL) and the NFL itself were hacked by the same group last month. The Olympics Facebook account does not appear to have been hacked. A hack known as the “Olympic Destroyer” took down Wi-Fi during the Opening Ceremony of the 2018 Winter Olympics in Pyeongchang also affected several broadcasts of the event by knocking out television screens. Read Also:No case for cancelling or postponing Tokyo 2020, World Health Organization tells IOC Pyeongchang 2018 websites were also hit, leaving fans unable to print tickets or view results of events. FacebookTwitterWhatsAppEmail分享 Promoted Content9 Movie Scenes That Got Re-Shot And Saved The Whole MovieA Soviet Shot Put Thrower’s Record Hasn’t Been Beaten To This DayTop 9 Scariest Haunted Castles In EuropeThe Best Cars Of All TimeWho’s The Best Car Manufacturer Of All Time?This Guy Photoshopped Himself Into Celeb Pics And It’s Hysterical13 kids at weddings who just don’t give a hoot5 Of The World’s Most Unique Theme Parks6 Ridiculous Health Myths That Are Actually TrueWho Is The Most Powerful Woman On Earth?8 Fascinating Facts About CoffeeBest & Worst Celebrity Endorsed Games Ever Madelast_img read more

7-Year Old Basketball

first_imgOn a recent trip to Iowa, I was able to watch my granddaughter play a basketball game at their local Y.  It is quite a scene to see first and second graders attempt to play a real game of basketball.  First of all, it is very unusual to have boys and girls playing on the same team.  Secondly, at this level the skill is quite different.When the game started, the boys would only pass the ball to the other boy or boys on the team and the girls seemed to do likewise.  To further complicate the flow of the game they seemed to seek out a friend to pass to rather than pass to an open teammate.  I think one little girl who attempted to find her friend threw the ball to the other team every time she had it.My granddaughter, as you would expect (ahem), was the best player on the floor!  She was the only player who could dribble the ball from one end of the floor to the other without traveling or having someone steel it from her.  I was quite proud of her when she got a rebound, dribbled the length of the floor, and shot the ball at the other end.  It was a fun experience for my wife and I.I was also impressed with the young man who coached these kids.  He would stop the game occasionally and explain to the young players what they were doing wrong but he did it in a very calm and relaxed manner.  He would then show them what they should be doing.  He really made the game fun for the kids which is what 7-year-old basketball should be about.  So glad we made this trip to Spencer, Iowa!last_img read more

Boys’ Track

first_imgCarmel High School has won a lot of state championships, but boys’ track has not been one of them.  Ken Browner led the Greyhounds to their 2nd state championship this year.  Ken and I are both members of the state track and cross country association board.  Carmel was not able to depend on winning a lot of events, so they knew they had to score points in every event in which they participated.  It was unusual that they did so in all but the one event they were supposed to win–the 4 x 800 relay.Many times state championships are won by having one outstanding individual as was the case of the girls’ championship this year.  This is the 5th state championship for Carmel this year.  They also won girls’ cross country & volleyball and both state swimming championships.  Carmel won over conference rivals Warren Central, Ben Davis, and Center Grove.   I would say this Indianapolis based conference had to be the state’s best in track and field this year.last_img read more